Uganda will welcome Egypt in the 2018 FIFA World Cup qualifier at the Mandela National Stadium in Kampala on Thursday.
Kick-off is at 15h00 CAT.
The Cranes will return to action for the first time since defeating Cape Verde 1-0 in the 2019 Africa Cup of Nations (AFCON) qualifier in Praia two months ago.
The team is now under the guidance of Moses Basena and Fred Kajoba, who are co-caretaker coaches following the departure of Milutin Sredojevic.
Farouk Miya, who is on the books of Belgian club Royal Excel Mouscron, is Uganda's dangerman and he will be looking to inspire his side to victory.
Uganda are placed second on the Group E standings with four points from two matches. They are two points behind group leaders, Egypt.
Meanwhile, Egypt will be hoping to bounce back to winning ways after losing 1-0 to Tunisia in the 2019 AFCON qualifier in Rades two months ago.
The Pharaohs are still under the guidance of veteran Argentine tactician, Hector Cuper, who guided Egypt to the 2017 AFCON finals.
Mohamed Salah, who is now playing for English giants Liverpool FC, is Egypt's star player and he will be hoping to help his nation overcome Uganda.
Egypt are sitting at the top of Group E table with six points from two games. They are ahead of second-placed Uganda with two points with four matches left.
Referee Ali Lemghaifry, who hails from Mauritania, will officiate the match between Uganda and Egypt in Kampala.
The return match is scheduled to be played at the Borg El Arab Stadium in Alexandria, Egypt next week Tuesday.