Champions Asante Kotoko travel to Sekondi to battle Hasaacas in the biggest match in mid-week in the Ghana top-flight.
The Porcupine Warriors will be on a tour of the country till the end of the season after they were handed a three match home ban at the Baba Yara stadium following crowd trouble.
The decision means, fans in Kumasi will not see their club in action at home and will need to make the journeys as the chase a third successive title in the Ghanaian elite division.
They are in the Western Region where they will play as guest of the giants of the West in a must win game for both sides.
For Kotoko, they will be keen to bag the maximum points and close in on their Premier League title surge.
They have opened a ten-point lead at the summit of the table with six games to spare including a game against sworn-rivals Kotoko.
There are no major injury worries for coach Mas-Ud Dramani as he inches closer to history.
Hasaacas will hope to return to winning ways and quick after losing back-to-back against Inter Allies.
Allies beat the 2-0 in the domestic League which followed their 1-0 win over the same side in the quarter-finals of the MTN FA Cup.
Coach Yusif Bassigi will require a positive response from his charges ahead of the visit of the Ghanaian powerhouse.
Hasmal are fourth on the table with 35 points, 15 adrift of their opponent.