Espérance de Tunis suffered their third successive defeat in the CAF Confederations Cup, going down 2-1 to a 10-man Stade Malien at Stade Olympique de Radès on Saturday.
The Malian outfit got off to an ideal start with Abdoulaye Sissoko finding the back of the net within six minutes.
The strike sparked a sense of urgency within the home side, who were rewarded soon after - Fakhreddine Ben Youssef with the equaliser on his competitive debut for the Tunisian outfit.
Smelling blood, the home side pressed for their second with Samuel Eduok and Iheb Mbarki seeing their respective efforts trouble the woodwork.
The 'Blood and Gold' were handed an extra boost with substitute Ibrahima Keita, who had replaced the injured injured Sadio Kanoute, seeing red following a second bookable offence just before the break.
Despite being a man light, it would be Malien to score next through Mamadou Coulibaly, three minutes after the interval.
The goal would prove to be enough as 'Les Blancs' held on to secure a memorable win.
The reverse fixture in Bamako will be played in two weeks time.