Defending Confederation Cup champions Al Ahly suffered a 1-0 loss to Etoile du Sahel in Sousse on Saturday night, losing their place at the top of Group A in the continental competition.
The Tunisians claimed their victory courtesy of a 26th minute penalty from Youssef Mouihbi, with the visitors unable to recover from going behind.
The result sees Etoile move to nine points and claim revenge after their loss to the Egyptians by the same score line in the previous matchday.
Ahly remain on seven points in second place, but could be caught by Stade Malien, who face Esperance in the other Group A match on Sunday.
Etoile will face Stade Malien in Bamako in their next Confed Cup match, while Ahly will be away to Esperance in Rades.